Ephrin-A4 Ligand (EFNA4) Predicts Poor Prognosis of Hepatocellular Carcinoma and Promotes Tumor Proliferation

Background/AimsPrimary hepatocellular carcinoma (HCC) is one of the most lethal tumor diseases in world. Receptor tyrosine kinases (RTKs) are thought to play a vital role HCC and Ephrin-A4 ligand (EFNA4) membrane-bound molecule that can activate RTKs through erythropoietin-producing (Eph) receptors. However, specific EFNA4 remains unknown. The aim our study was explore prognostic value expression HCC.MethodsBioinformatics analyses were conducted probe levels HCC. quantitative real-time polymerase chain reaction, immunohistochemical western blot used confirm paired clinical specimens Colony formation assay proliferation cell.ResultsThe generally elevated various cancers. Especially, upregulated tissue associated with stage patients. patients lower possessed better survival progression-free times. indicated overexpression promoted cell proliferation.ConclusionThese results demonstrated played as an oncogenic gene biomarker for Primary Bioinformatics cell. proliferation. These